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Nádory tenkého čreva patria medzi zriedkavé

Napísal TS OZ Zriedkavé choroby 30. apríl 2020

Tretia časť osvetového videoseriálu o TOP slovenských pracoviskách pre zriedkavé choroby predstavuje Oddelenie klinickej onkológie E, ktoré patrí pod II. Onkologickú kliniku LFUK a NOÚ. Viac ako 20 rokov sa venuje liečbe nádorov tráviaceho traktu, malígneho melanómu a tiež pľúc a hrudníka.

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Aj keď sa oddelenie, kde ročne hospitalizujú vyše 1 100 pacientov z celého Slovenska, primárne zameriava na liečbu nádorov zažívacieho ústrojenstva, ktoré patria v onkológii k najčastejším, i tu sa stretávajú s raritnejšími diagnózami. „Ide najmä o karcinómy pažeráka, tenkého čreva, análneho kanála, vzácne formy rakoviny pečene, nádory pohrudnice, melanómy oka, ale tiež neuroendokrinné nádory, ktoré môžu postihnúť akýkoľvek orgán. Kľúčom k ich diagnostike sú moderné genetické vyšetrenia, ktoré prispeli k účelnejšej klasifikácii nádorov a tým aj k cielenejšej liečbe,“ hovorí primár oddelenia MUDr. Jozef Dolinský.

Kým štatistiky nádorových ochorení tráviacej sústavy neslávne vedie hrubé črevo, a to ako na Slovensku tak i v Európe, susediace tenké črevo, kde prebieha najdôležitejšia časť trávenia, je na tom z pohľadu výskytu opačne. Nádory tenkého čreva patria k zriedkavým, predstavujú zhruba 1 až 2% všetkých nádorov zažívacieho traktu. Ročne je v NOÚ diagnostikovaných približne 60 pacientov.

V súčasnosti veľmi významne stúpa aj výskyt nádorov pankreasu, ktoré patria k mimoriadne zákerným ochoreniam, aj kvôli tomu, že z dôvodu dlhej bezpríznakovosti sa často diagnostikujú až v pokročilých štádiách. K zriedkavým diagnózam tu patria neuroendokrinné nádory, ktoré v porovnaní so štandardnými adenokarcinómami pankreasu majú ale oveľa priaznivejšiu prognózu. „Mali sme tu napríklad pacienta diagnostikovaného v 54. roku života, ktorý v súčasnosti prežíva s diagnózou neuroendokrinného nádoru pankreasu 14-ty rok,“ vysvetľuje klinická onkologička z oddelenia, MUDr. Silvia Jurišová.

O charaktere nádoru pankreasu ako žľazy s vonkajším - exokrinným a vnútorným - endokrinným vylučovaním rozhoduje typ buniek, z ktorého je zhubný nádor tvorený. Neuroendokrinné nádory vznikajú z endokrinných buniek, ktoré majú na starosti produkciu hormónov ako napríklad inzulín ovplyvňujúci hladinu cukru v krvi. Štandardné adenokarcinómy (zhubné nádory buniek výstelkového tkaniva) pankreasu vznikajú z exokrinnej časti, ktorá tvorí 95% pankreasu a je zodpovedná za tvorbu pankreatickej šťavy napomáhajúcej tráveniu.

Pre akýkoľvek typ nádoru, pri zriedkavých diagnózach o to viac, je kľúčová diagnostika. Na pomoc jej v posledných rokoch okrem patológie prichádzajú moderné genetické metódy, ktoré zásadným spôsobom menia klasifikáciu nádorov. Inak povedané, kým sa jednotlivé nádory kedysi definovali podľa časti tela, orgánu alebo neskôr bunky, z ktorej vychádzali, moderná genetická diagnostika ide hlbšie do vnútra bunky, až na úroveň génov. Výsledkom je zacielenie liečby na časť DNA, ktorá spustila nádorové bujnenie a to v kontexte liečby posúva medicínu o výrazný krok ďalej.

Pozrite si tretiu časť videoseriálu TOP pracoviská pre zriedkavé choroby, ktoré pripravuje OZ Zriedkavé choroby. V seriáli sú postupne predstavované slovenské pracoviská a špičkoví odborníci. https://www.zriedkavechoroby.sk/kde-hladat-pomoc/videoserial-top-pracoviska/

Seriál je prístupný aj na YouTube kanáli OZ Zriedkavé choroby:


 Kto je OZ Zriedkavé choroby:

Občianske združenie Zriedkavé choroby odštartovalo svoju činnosť v roku 2018. Špecializuje sa na zriedkavé choroby, ktorými môže na Slovensku trpieť až 300-tisíc Slovákov. Na svojom portáli www.zriedkavechoroby.sk ponúka komplexné informácie, aktuality, zoznamy odborníkov a špecializovaných pracovísk, odborných zahraničných zdrojov a platforiem. Na portáli sa nachádza pravidelne aktualizovaná podstránka skutočných pacientskych príbehov, s opismi príznakov chorôb. Združenie poskytuje pacientom a ich blízkym poradenstvo, pomoc a tiež služby krízovej intervencie.

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    Doing your side laterals on a cable machine is
    a lot better than with dumbbells because it allows for early phase loading
    while also keeping fixed rigidity on the delts throughout the motion. Most people consider their trapezius as
    solely consisting of the area between their neck and their shoulders.
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    the center trapezius is the scapular retraction with a double pulley cable machine.
    Let’s look at what the upright row is and what it
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    article good options to it. The upright row is
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    He’s not simply an armchair fitness skilled; Patrick practices what
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    Some lifters find it onerous on their wrists to perform overhead workouts with the
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    Fewer realize that they also work the upper trapezius
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    The upright row is a vertical pulling exercise and
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    An overwhelming biceps pump through the exercise is
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    However they hit the muscles in one other way due to the position of
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    Leaning away from the cable machine also implies that you’re working the
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    A leg press machine is generally a plate-loaded machine, that means
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    The hack squat is a sort of squat that is carried
    out in a method to put extra focus on the quadriceps with an upright
    back.
    Nonetheless, superior lifters might require a fantastic challenge,
    employing the brutality of the hack squat, belt squat,
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    Research indicate that performing units of eight to 12
    repetitions at 60%-80% of your 1RM is ideal for promoting muscle hypertrophy.
    Research means that performing sets of one to 5 reps at 80%-100% of
    your one repetition most (1RM) is helpful for improving strength.

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    Arguably the preferred leg exercise machine at the fitness center, the leg press is a wonderful supplementary train to squatting.

    The support of the device means less stability and coordination are required.